Senior Associate Scientist, Ophthalmology

The Ophthalmology Research team is seeking a Senior Associate Scientst to support preclinical research activities focused on retinal and ocular diseases. This role is well suited for a highly motivated, hands on Senior Associate Scientist with experience across in vitro and/or in vivo experimental systems, with exposure to or developing expertise in rodent in vivo retinal imaging, ocular dissections, and retinal disease models.

The Senior Associate Scientist will contribute to experimental execution, robust data generation, and day to day scientific operations within a collaborative, multidisciplinary research environment, working closely with more senior scientists.

This position is onsite and will be primarily located in Cambridge, MA.

Key Responsibilities

• Support experimental planning and execute in vitro and in vivo studies for ophthalmology research programs advancing RNAi therapeutic development, under guidance as needed.
• Perform and support rodent in vivo retinal imaging techniques, including:
• Optical coherence tomography (OCT)
• Fundus photography / fundoscopy
• Fluorescein and/or OCT angiography (FA/OCTA)
• Execute and assist with preclinical retinal disease models (e.g., laser induced CNV, OIR/ROP, diabetic retinopathy, glaucoma, geographic atrophy) following established protocols, with training provided for models new to the candidate.
• Conduct ocular tissue dissections, including retina, RPE/choroid, optic nerve, and anterior segment, for downstream molecular, imaging, and histological analyses.
• Perform in vivo pharmacology studies assessing pharmacodynamics, biodistribution, efficacy, and safety in ocular tissues.
• Develop, optimize, and routinely perform in vitro assays and cellular models relevant to retinal biology.
• Accurately collect, analyze, and document experimental data; contribute to data interpretation and presentation in collaboration with project team members.
• Work closely with colleagues across discovery, delivery, genetics, and translational research functions to support program progression.
• Prepare internal experimental summaries, reports, and presentations.
• Maintain laboratory organization, documentation, and compliance with scientific best practices and reproducibility standards.

Qualifications

Required

• Minimum B.S. degree in a life sciences-related discipline.
• 3-5 years of experience in ophthalmology, vision research, or a closely related biological research field, gained through industry, academic, or equivalent roles.
• Experience with in vitro and/or in vivo experimental techniques, with the ability to learn and apply new methods in a preclinical research environment.
• Experience handling ocular or neural tissues, or demonstrated aptitude for learning ocular dissection techniques.
• General working knowledge of retinal anatomy and ocular disease biology.
• Background exposure to retinal disease indications such as AMD, DME, ROP, and/or glaucoma.
• Strong organizational skills, attention to detail, and the ability to manage multiple experiments or projects simultaneously.
• Effective written and verbal communication skills and the ability to work productively within a collaborative, team based research environment.

Preferred

• Experience performing rodent in vivo retinal imaging (e.g., OCT, fundoscopy, FA).
• Direct experience with preclinical retinal disease models (e.g., laser CNV, OIR/ROP, DR, glaucoma).
• Experience conducting ocular dissections (retina, RPE/choroid, optic nerve, anterior segment).
• Familiarity with quantitative image analysis tools or imaging software.
• Exposure to RNAi, genesilencing technologies, or ocular drug delivery approaches.
• Experience contributing to regulated preclinical studies or working with CROgenerated data.
• Demonstrated interest in scientific skill development and progression within a researchfocused career path.

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U.S. Pay Range

$80,000.00 - $120,000.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

AboutAlnylam

We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.