Senior Director, Global Trial Strategy & Operations

The Senior Director, Global Trial Strategy & Operations is a strategic operational leader responsible for driving disciplined execution, portfolio-level planning, and operational excellence across the Cardiovascular and TTR portfolio. This role reports directly to the Vice President, Study Management and works in close partnership to design, and/or operationalize strategic priorities, ensure alignment to critical path, and elevate delivery standards across studies.

The Senior Director influences execution through operational strategy, planning frameworks, portfolio insights, prioritization, governance, and cross-functional alignment. The role partners closely with study and program leadership to ensure operational strategies are robust, documented, actively managed, and informed by risk.

The role may represent the portfolio and VP, Study Management in selected leadership forums, enabling alignment, continuity of strategy, and visibility to progress and risks. Additionally, the Senior Director contributes to organizational evolution by developing standards, best practices, and processes that enhance scalability, quality, and trial efficiency across the portfolio.

The Senior Director, Global Trial Strategy & Operations ensures high-quality execution across programs through strategic influence, operational frameworks, and portfolio-level visibility. He/she partners with program, study, and functional leaders to drive disciplined planning, milestone transparency, risk mitigation, and alignment to strategic priorities.

Reporting directly to the VP, Study Management, the Senior Director works in close collaboration to operationalize strategic priorities across the Cardiovascular and TTR portfolio. Acting on behalf of the VP when delegated, he/she may represent the portfolio in leadership and governance settings to reinforce alignment and support informed, timely decision-making.

He/she may/may not manage direct reports but drives impact by influencing delivery and team effectiveness through clarity of expectations, strategic frameworks, and cross-functional alignment. He/she ensures that teams operate with rigor, that plans are well defined and maintained, and that performance insights drive continuous improvement across the portfolio.

He/she contributes to the continued evolution of Clinical Operations and GTSO by participating in and leading initiatives, establishing scalable practices, operating models, and delivery standards that enhance efficiency, quality, consistency, and inspection readiness.

He/she will work closely with CRO partners to ensure aligned execution against scope of work, proactive risk management, and focus on critical path and priority deliverables. This includes developing best practices for vendor oversight, communication cadence, issue escalation, and performance monitoring across the Cardiovascular and TTR portfolio.

The Senior Director will also assist in financial oversight across programs, including budget tracking, investment planning cycles, annual operating planning, and long-range planning. Additionally, he/she will partner closely with other clinical operations functions-including SM&H, GTO, CPS, and cross-functional program teams-to ensure alignment, process improvements, and delivery excellence.

• Partner across Clinical Operations, study teams, and cross-functional partners to drive strategic operational planning, including defining approaches, execution assumptions, timelines, risk management strategies, and delivery frameworks.
• Develop portfolio-level tracking mechanisms, dashboards, KPIs, and performance analytics to support transparency and data-driven decision-making.
• Drive prioritization and scenario planning across the Cardiovascular and TTR portfolio, ensuring alignment to critical path and effective deployment of resources.
• Represent the portfolio in leadership and governance forums, when delegated, ensuring continuity of strategy, alignment, and clarity of decision pathways.
• Develop, institutionalize, and continuously refine best practices, operating models, playbooks, and standards that reinforce planning rigor, predictable execution, and operational excellence.
• Partner with study and program leaders to ensure operational plans are documented, actively managed, and responsive to risks, external changes, and portfolio dependencies.
• Collaborate with cross-functional leaders to support operational readiness, including inspection readiness, vendor oversight frameworks, and compliance.
• Establish and evolve operating rhythms and governance structures that streamline communication, clarify accountability, and enable timely decisions across programs.
• Serve as a strategic thought partner to elevate execution focus, challenge assumptions, integrate lessons learned, and support continuous improvement.
• Partner closely with CROs and external vendors to ensure proactive execution, scope adherence, and high-quality delivery while establishing best practices for oversight.
• Assist in financial oversight across programs, including forecasting, budget management, investment planning, and long-range portfolio planning.
• Partner with SM&H, GTO, CPS, and other clinical operations groups to align strategies, improve processes, and drive portfolio delivery.

• Bachelor's degree in Life Sciences or related field required; advanced degree preferred.
• 12+ years of experience in global clinical trial execution within biopharma or CRO environments, with deep operational leadership across full study lifecycle.
• Demonstrated success operating as a direct report to senior executives and partnering closely at the leadership level to translate strategic priorities into operational execution.
• Proven track record influencing without direct authority across senior operational and functional leadership.
• Expertise in clinical operations strategy, program planning, risk management, trial delivery models, and cross-functional execution.
• Experience developing or implementing operational frameworks, governance models, or delivery standards.
• Strong presence in senior forums with ability to synthesize complex information and drive alignment through compelling communication.
• Strong understanding of global regulatory expectations and compliance requirements for clinical trial conduct.
• Excellent written, verbal, and presentation communication skills.
• Ability to travel up to 30%.

• Highly self-directed with ability to drive execution across multiple programs simultaneously.
• Strong critical thinking, analytical rigor, and ability to navigate ambiguity and drive clarity of action.
• Skilled influencer able to align diverse stakeholders around shared priorities.
• Comfortable operating across geographies and time zones in a complex matrix environment.
• Demonstrated ability to drive impact through strategic frameworks, insights, and alignment rather than formal authority.
• Operates effectively in a dynamic, fast-paced environment with evolving organizational needs.

U.S. Pay Range

$228,800.00 - $309,600.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

AboutAlnylam

We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.