Modeling and Simulations Scientist, Clinical Pharmacology

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The Clinical Pharmacology Department at Genentech, Inc. is seeking Ph.D. level Senior/Principal Scientist who is driven to use cutting edge modeling approaches to advance the clinical development of novel drug candidates to join our diverse group of pharmacometricians, system modelers, advanced programmers, and artificial intelligence/machine learning scientists. This individual will be responsible for the development and implementation of Modeling and Simulation (M&S) strategy, in order to ensure that the right drug is administered to the right patient at the right dosing regimen. The modeling and simulation activities include population PK/PD models, disease models, statistical models, physiologically-based PK (PBPK) models, quantitative system pharmacology (QSP) models, clinical trial simulations, literature meta-analysis, machine learning/deep learning, and other state of the art quantitative techniques. Key technical responsibilities are to organize, execute, and report M&S independently, as well as to present work at cross-functional teams, department meetings, senior management review committees, regulatory interactions, and scientific conferences. Other responsibilities will include planning, writing, and reviewing relevant clinical documents such as study protocols, analysis plans, reports, and regulatory documents. These will be accomplished by working in close partnership with other scientists in Clinical Pharmacology, Clinical Science, Biostatistics, Translational PKPD, DMPK, Translational Safety, Biomarker, Diagnostics, Regulatory, RWD (Real World Data), and other functions on project teams. Qualified candidate could be responsible to provide oversight of the strategy and implementation of M&S by other scientists. The successful candidate should be a forward thinking scientist capable to work effectively across diverse regions, cultures, and time zones, creating an environment of belonging, inclusion and diversity.

Opportunity:

As an integral member of this dynamic team, you will have:

• Solid expertise in quantitative pharmacology and strong hands-on modeling and simulation skills.

• Hands-on experience with R, NONMEM, SimBiology, Simcyp, GastroPlus, Python, and/or other modeling and simulation software

• Experience with advanced statistical modeling, clinical trial simulation, optimal design, QSP modeling, and/or cutting-edge machine learning technologies (highly preferred).

• Experience in interaction with regulatory agencies

• Excellent communication and interpersonal skills, as well as the demonstrated ability to work effectively in cross-functional project teams. The candidate should thrive and work well in a fast-paced, multi-tasked, and hands-on environment.

• Demonstrated impact on drug development through quantitative approaches

• A strong track-record of leadership skills and success in influencing senior stakeholders is critical for success.

• People management experience (preferred)

Who You Are:

• A Ph.D. or equivalent in Pharmacometrics, Data Science, Biostatistics, Biomedical or Chemical Engineering, Applied Mathematics or Physics, Pharmaceutical Sciences, or related discipline with 0+ year (for Senior Scientist), 3+ years (for Principal Scientist)

• Experience in Modeling and Simulating

Relocation benefits are available for this posting.

The expected salary range for this position based on the primary location of California is $101,500-$232,900 (Senior Scientist) and $148,200-$275,200 (Principal Scientist) . Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

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