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Principal Scientist I/II, Radioligand Modeling & Simulation

Novartis Group Companies
parental leave, paid time off, sick time, 401(k)
United States, Massachusetts, Cambridge
Jan 30, 2025
Job Description Summary #LI-Hybrid About the role: We are seeking a translational or clinical modeler eager to accelerate radioligand discovery & development by facilitating rigorous decision making with modeling & simulation. You will work in a multi-disciplinary environment, with opportunities to engage in cross-functional initiatives. This role reports to a PK Sciences Translational Modeling team lead, in a group situated within Biomedical Research, the research engine of Novartis. Job Description Key Responsibilities: Act as the Translational M&S representative on radioligand therapy programs, developing and executing modeling strategies, contributing to project team discussions, and guiding therapeutic design and dose selection decisions. Build and apply innovative QSP and physiologically based PK (PBPK) models along with dosimetry estimations to link RLT pharmacology, tissue biodistribution, mechanism(s) of action, and biological and clinical outcomes. Contribute to an integrated RLT modeling platform that bridges data and knowledge across preclinical species and patients, partnering with discovery project teams as well as the preclinical safety and pharmacometrics groups. Implementing innovating quantitative approaches to advance the translational science for radiopharmaceuticals. Proactively seek opportunities to increase the impact and awareness of translational and clinical modeling through communications with internal and external audiences. Essential requirements Ph.D. in biology, pharmaceutical sciences, bioengineering, biophysics, or a related field along with demonstrated expertise in radiobiology / nuclear medicine. To be considered at the Principal Scientist II level must have 2-3 years plus related experience ideally in industry. Prior experience in pharmacokinetics and pharmacodynamics (PK/PD), quantitative systems pharmacology (QSP), and/or physiologically based PK (PBPK) modeling is preferred. Expert level proficiency in core modeling fundamentals is required, including scripting languages (e.g., MATLAB, R), construction of differential equation based models, parameter estimation, and data visualization. Demonstrated ability to communicate modeling results to a multidisciplinary audience to facilitate decision-making. This is a dual level posting. The final level and title of the offer role would be determined by the hiring team based on the skills, experience & capabilities required to perform the role at the level the role has been offered. Commitment to Diversity and Inclusion / EEO: The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential. Novartis Compensation and Benefit Summary: The pay range for this position at commencement of employment is expected to be between $119,700 to $222,300/year; however, while salary ranges are effective from 1/1/25 through 12/31/25, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills, and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an "at-will position" and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors. #ModelingAndSimulation #PKSciences #TranslationalMedicineQuants EEO Statement: The Novartis Group of Companies are Equal Opportunity Employers who are focused on building and advancing a culture of inclusion that values and celebrates individual differences, uniqueness, backgrounds and perspectives. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to fostering a diverse and inclusive workplace that reflects the world around us and connects us to the patients, customers and communities we serve. Accessibility and reasonable accommodations The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to us.reasonableaccommodations@novartis.com or call +1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Salary Range $119,700.00 - $222,300.00 Skills Desired Algorithms, Data Engineering, Innovation, Mentorship, Modeling And Simulation, Simulation Software, Waterfall Model